Synthesis and pharmacology of a series of 3-and 4-(phosphonoalkyl) pyridine-and-piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists

PL Ornstein, JM Schaus, JW Chambers…

Index: Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833

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Citation Number: 58

Abstract

We recently prepared a series of 3-and 4-(phosphonoalkyl) pyridine-and-piperidine-2- carboxylic acids tu antagonists of neurotransmission at N-methyl-D-aspartate (NMDA) preferring receptors. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsants, in the treatment of neurodegenerative disorders such as Alzheimer's disease and in the prevention of neuronal damage that occurs during cerebral ...