Tetrahedron

Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution

M Muthukrishnan, DR Garud, RR Joshi, RA Joshi

文献索引：Tetrahedron, , vol. 63, # 8 p. 1872 - 1876

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被引用次数: 29

摘要

... Tetrahedron. Volume 63, Issue 8, 19 February 2007, Pages 1872–1876. ... A solution of (S)-8 (0.7 g, 0.003 mol) in i-PrNH 2 (2.5 mL) and H 2 O (2–3 drops) was refluxed until TLC showed the reaction had gone to completion (10 h). Removal of the solvent yielded the crude (S ...