Allyl as Protective Group for the Acidic Hydrogen of Malonic Ester

T Yamazaki, A Kasatkin, Y Kawanaka…

文献索引：Yamazaki, Takanori; Kasatkin, Aleksandr; Kawanaka, Yasufumi; Sato, Fumie Journal of Organic Chemistry, 1996 , vol. 61, # 7 p. 2266 - 2267

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被引用次数: 26

摘要

The malonic ester synthesis is one of the most fundamental methodologies in organic synthesis. 1 The reaction has been widely used for the preparation of mono-and disubstituted acetic acids via mono-and dialkylation, respectively, and subsequent hydrolysis and decarboxylation. The presence of two acidic hydrogens in the starting compound, however, sometimes causes difficulty in applying this methodology in organic ...