Resolution of 5-Vinyl-2-pyrrolidinone. A Practical Synthesis of (S)-and (R)-Vigabatrin

ZY Wei, EE Knaus

文献索引：Wei, Z. Y.; Knaus, Edward E. Organic Preparations and Procedures International, 1994 , vol. 26, # 5 p. 567 - 570

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被引用次数: 2

摘要

Vigabatrin (y-vinyl GABA, 4-amino-5-hexenoic acid) is a highly selective enzyme-activated inhibitor of GABA-T in mammalian brain,'which crosses the blood-brain-barrier (BBB), and is used clinically primarily to control seizures refractory to other anticonvulsant drugs.'(S)- Vigabatrin is the pharmacological active enantiomer, whereas the (R)-antipode is inactive. The two enantiomers of vigabatrin have been prepared by asymmetric syntheses,'-'or by ...