The Journal of Organic Chemistry

A short efficient synthesis of (S)-4-amino-5-hexenoic acid [(S)-vigabatrin]

ZY Wei, EE Knaus

文献索引：Wei, Zhong-Yong; Knaus, Edward E. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1586 - 1588

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被引用次数: 17

摘要

The brain concentrations of the excitatory L-glutamate and inhibitory 7-aminobutyric acid (GABA, 1) neurotranemitters are regulated primarily by the two pyridoxyl 5'-phosphate dependent enzymes L-glutamic acid decarboxylase (GAD) that catalyzes the conversion of L-