Designed calix [8] arene-based ligands for selective tryptase surface recognition

T Mecca, GML Consoli, C Geraci, F Cunsolo

文献索引：Mecca, Tommaso; Consoli, Grazia M.L.; Geraci, Corrada; Cunsolo, Francesca Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5057 - 5062

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被引用次数: 51

摘要

Basic amino acid calix [8] arene receptors for tryptase surface recognition have been synthesized. The tetrameric arrangement and the negative charge distribution close to the active sites of the enzyme, have suggested the design of complementary multifunctional receptors that might bind to the active region of the protein blocking the approach of the substrate. Kinetic inhibition analysis on recombinant lung tryptase have showed a time- ...