Designed calix [8] arene-based ligands for selective tryptase surface recognition

T Mecca, GML Consoli, C Geraci, F Cunsolo

Index: Mecca, Tommaso; Consoli, Grazia M.L.; Geraci, Corrada; Cunsolo, Francesca Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5057 - 5062

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Citation Number: 51

Abstract

Basic amino acid calix [8] arene receptors for tryptase surface recognition have been synthesized. The tetrameric arrangement and the negative charge distribution close to the active sites of the enzyme, have suggested the design of complementary multifunctional receptors that might bind to the active region of the protein blocking the approach of the substrate. Kinetic inhibition analysis on recombinant lung tryptase have showed a time- ...