Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors

…, W Namkung, AS Verkman, PK Sharma

文献索引：Kumar, Satish; Namkung, Wan; Verkman; Sharma, Pawan K. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4237 - 4244

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被引用次数: 22

摘要

Transmembrane protein 16A (TMEM16A) channels are recently discovered membrane proteins that functions as a calcium activated chloride channel (CaCC). CaCCs are major regulators of various physiological processes, such as sensory transduction, epithelial secretion, smooth muscle contraction and oocyte fertilization. Thirty novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids (B01–B30) were synthesized and ...