Kumada coupling of aryl and vinyl tosylates under mild conditions

ME Limmert, AH Roy, JF Hartwig

文献索引：Limmert, Michael E.; Roy, Amy H.; Hartwig, John F. Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9364 - 9370

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被引用次数: 156

摘要

Aryl and alkenyl tosylates are easily prepared, inexpensive and, thus, attractive for transition- metal-catalyzed couplings, but their reactivity is low. We report examples of mild, palladium- catalyzed coupling of aryl, alkenyl, and alkyl Grignard reagents with aryl and alkenyl tosylates. The resulting biaryls, vinylarenes, and alkylarenes were isolated in good to excellent yield. These couplings were conducted with a nearly equimolar ratio of the two ...