Stereocontrol by introduction of a sulfur functional group in the asymmetric reduction of β-ketoesters with baker's yeast; preparation of optically pure 3s- …
Abstract Asymmetric reduction of β-ketothioester derivatives with baker's yeast produced the corresponding optically pure 3S-hydroxyethioesters, which are useful chiral building blocks in organic synthesis. The utility of the present method was demonstrated in the stereoselective synthesis of sex attractant of pine saw-fly,(2S, 3S, 7S)-5, 7-dimethylpentadec- 2-yl acetate from the SS-hydroxy esters.
