The product of Baker's yeast reduction of ethyl 2-chloro-3-oxobutanoate as a precursor of the 1-ethoxycarbonyl 2 (S)-hydroxypropyl radical

M Hamdani, B De Jeso, H Deleuze, A Saux…

文献索引：Hamdani, Mourad; Jeso, Bernard De; Deleuze, Herve; Saux, Annie; Maillard, Bernard Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1233 - 1236

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被引用次数: 16

摘要

Abstract Baker's yeast treatment of ethyl 2-chloro-3-oxobutanoate 1, diethyl 2- acetylmalonate 2 and ethyl 2-cyano-3-oxobutanoate 3 was effected in order to obtain enantiomerically enriched compounds. In contrast to the reaction of 2 and 3, efficient diastereo-and enantioselective reduction of 1 provided ethyl 2 (R)-chloro-3 (S)- hydroxybutanoate. This product was used as precursor of the 1-ethoxycarbonyl-2 (S)- ...