A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorder. The isoindoline compounds were prepared by reduction of the corresponding phthalimides with LiAlH4. One compound was not chiral, and the other two required an enantioselective ...
[Alexandre, Francois-Rene; Pantaleone, David P.; Taylor, Paul P.; Fotheringham, Ian G.; Ager, David J.; Turner, Nicholas J. Tetrahedron Letters, 2002 , vol. 43, # 4 p. 707 - 710]
