Amine–boranes: effective reducing agents for the deracemisation of dl-amino acids using l-amino acid oxidase from Proteus myxofaciens
…, PP Taylor, IG Fotheringham, DJ Ager, NJ Turner
文献索引：Alexandre, Francois-Rene; Pantaleone, David P.; Taylor, Paul P.; Fotheringham, Ian G.; Ager, David J.; Turner, Nicholas J. Tetrahedron Letters, 2002 , vol. 43, # 4 p. 707 - 710
The deracemisation of dl-α-amino acids using l-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of d-amino acids were obtained in yields of up to 90% and ee> 99%.
