前往化源商城

Synthesis of novel cyclic sulfone dihydropyridines facilitated by a selective ethyl diazoacetate ring expansion

…, CF Schwender, Y Gray??Nunez

文献索引:Dodd, John H.; Schwender, Charles F.; Gray-Nunez, Yolanda Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1453 - 1456

全文:HTML全文

被引用次数: 14

摘要

Abstract A series of novel cyclic sulfone dihydropyridines with five to nine membered rings have been synthesized. Anomalous intermediates isolated from the Hantzch condensation were found to vary depending on the sulfone ring size and aromatic substitution. Tin tetrachloride has been shown to be a superior Lewis acid catalyst for ethyl diazoacetate ring expansion of the requesite β-keto cyclic sulfone precursors.