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The chemistry of indoles. XXIV. Syntheses of 3-indoleacetic acid and 3-indoleacetonitrile having a halogeno group and a carbon functional group at the 4-position

…, K Kizu, M Kunimoto, F Yamada

文献索引:Somei; Kizu; Kunimoto; Yamada Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3696 - 3708

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被引用次数: 50

摘要

抄録: Various 4-halogeno-3-indoleacetic acids and-3-indoleacetonitriles were synthesized for the first time by means of the Sandmeyer or Schiemann reaction, demonstrating the versatility of 4-indolediazonium salts in 4-substituted indole chemistry. A practical synthetic method for 4-halogenoindoles was developed by regio-selective thallation-halogenation, and the products were also led to 4-halogeno-3-indoleacetic acids. The first synthesis of 4 ...

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