Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory …

Z Getahun, L Jurd, PS Chu, CM Lin…

文献索引：Getahun, Zelleka; Jurd, Leonard; Chu, Ping S.; Lin, Chii M.; Hamel, Ernest Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1058 - 1067

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被引用次数: 67

摘要

A number of cytostatic compounds (2-4, 7, and 8), which can be described as “diaryl”, inhibit tubulin polymerization, cause cells to accumulate in mitotic arrest, and competitively inhibit the binding of colchicine to tubulin. They differ, however, in the separation of the two aryl moieties. To attempt to understand this variability we prepared a series of analogues modeled on 3 and 4 ('benzodioxole series”) and on 7 and 8 ('combretastatin aeries”) ...