2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors

…, M Selvaraj, L Botta, M Sampaolo, D Saita…

文献索引：Tiberi, Marika; Tintori, Cristina; Ceresola, Elisa Rita; Fazi, Roberta; Zamperini, Claudio; Calandro, Pierpaolo; Franchi, Luigi; Selvaraj, Manikandan; Botta, Lorenzo; Sampaolo, Michela; Saita, Diego; Ferrarese, Roberto; Clementi, Massimo; Canducci, Filippo; Botta, Maurizio Antimicrobial Agents and Chemotherapy, 2014 , vol. 58, # 6 p. 3043 - 3052

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被引用次数: 4

摘要

ABSTRACT We report here the synthesis of 2-aminothiazolones along with their biological properties as novel anti-HIV agents. Such compounds have proven to act through the inhibition of the gp120-CD4 protein-protein interaction that occurs at the very early stage of the HIV-1 entry process. No cytotoxicity was found for these compounds, and broad antiviral activities against laboratory strains and pseudotyped viruses were documented. Docking ...