A Versatile and Practical Synthesis toward the Development of Novel HIV??1 Integrase Inhibitors

…, L Franchi, G Vignaroli, A Innitzer, S Massa…

文献索引：Rinaldi, Marta; Tintori, Cristina; Franchi, Luigi; Vignaroli, Giulia; Innitzer, Anna; Massa, Silvio; Este, Jose A.; Gonzalo, Encarna; Christ, Frauke; Debyser, Zeger; Botta, Maurizio ChemMedChem, 2011 , vol. 6, # 2 p. 343 - 352

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被引用次数: 9

摘要

Abstract As a continuation of our previous work, which resulted in the identification of a new hit compound as an HIV-1 integrase inhibitor, three novel series of salicylic acid derivatives were synthesized using three versatile and practical synthetic strategies and were assayed for their capacity to inhibit the catalytic activity of HIV-1 integrase. Biological evaluations revealed that some of the synthesized compounds possess good inhibitory potency in ...