New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90

G Le Bras, C Radanyi, JF Peyrat, JD Brion…

文献索引：Bansal, Vandana; Kanodia, Saraswati; Thapliyal, Prakash C.; Khanna, Rajinder N. Synthetic Communications, 1996 , vol. 26, # 5 p. 887 - 892

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被引用次数: 101

摘要

... Among the synthetic derivatives, compounds 6c, 6e, and 6f showed the most potent inhibitory activity against the proliferation of ... conditions: (i) ArC⋮CH, PdCl 2 (PPh 3 ) 2 , PPh 3 , CuI, Et 3 N, dioxane, 100 °C sealed tube; (ii) PTSA, EtOH, microwave, 120 °C or 170 °C, 0.5 h. ...