Synthesis of a focused chemical library based on derivatives of embelin, a natural product with proapoptotic and anticancer properties

G Viault, D Grée, S Das, JS Yadav…

文献索引：Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241

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被引用次数: 21

摘要

Abstract The synthesis of new derivatives of embelin, a natural inhibitor of X-linked inhibitor of apoptosis protein (XIAP) is described. The design of these new molecules involved introduction of aromatic groups directly linked to the benzoquinone core. To allow a large flexibility in the nature and the length of the added chain, the strategy involves first aSuzuki– Miyaura reaction with functionalized aromatics, yielding a first generation of molecules. ...