Tetrahedron letters

One-pot synthesis of secondary or tertiary amines from alcohols and amines via alkoxyphosphonium salts

P Frøyen, P Juvvik

文献索引：Froyen, Paul; Juvvik, Paul Tetrahedron Letters, 1995 , vol. 36, # 52 p. 9555 - 9558

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被引用次数: 14

摘要

Secondary or tertiary amines may be prepared from primary alcohols and primary or secondary amines by treating triphenylphosphine with N-bromosuccinimide (NBS) in the presence of the alcohol at low temperature, followed by addition of the amine and heating for about 1 h. The yield of amine is good to fair, decreasing sharply with sterically congested alcohols and starting amines.