Functionalized nitrogen atom transfer catalyzed by cytochrome P-450

…, JH Dawson, R Breslow, SH Gellman

文献索引：Breslow, Ronald; Gellman, Samuel H. Journal of the American Chemical Society, 1983 , vol. 105, # 22 p. 6728 - 6729

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被引用次数: 93

摘要

Cytochrome P-450-LM3, 4 has been found to catalyze intramolecular amidation (1-2), as evidenced by multiple turnovers (2.2) of the enzyme under optimal condition^.'^ The reaction rate, as determined by product 2 formation,'3b is linearly dependent on P-450 concentration (0-1 MM), time (0-3 min), and substrate (1) concentration (0-0.53 mM), with a turnover number14 of 1.0 for the LM3, 4 isozyme mixture, a value that is a lower limit since ...