Herein, we report the solid-phase synthesis of several 5-aminoimidazole-4-(N-alkyl) carboxamide-1-ribosides (4-N-alkyl AICARs) and the corresponding 2′, 3′-secoriboside derivatives. The method uses the N-1-dinitrophenyl-inosine 5′-bonded to a solid support. This inosine derivative has the C-2 of the purine base strongly activated towards the attack of N-nucleophiles thus allowing the preparation of several N-1 alkylated inosine supports ...
