Journal of medicinal chemistry

Synthesis, activation, and cytotoxicity of aldophosphamide analogs

RF Borch, RR Valente

文献索引：Borch, Richard F.; Valente, Ronald R. Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3052 - 3058

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被引用次数: 25

摘要

A series of perhydrooxazine analogues of aldophosphamide has been prepared, and their slP NMR kinetics and in vitro cytotoxicity have been evaluated. These compounds were developed on the basis of the idea that ring opening and tautomerization to an enamine intermediate might provide a mechanistic alternative to the &elimination reaction for release of phosphoramide mustard. The 4, 4, 6-trimethyltetrahydro-l, 3-oxazine moiety was ...