Mechanism and processing parameters affecting the formation of methyl methanesulfonate from methanol and methanesulfonic acid: an illustrative example for …

…, S Golec, R Schulte Oestrich, P Sandra…

文献索引：Magnus, Nicholas A.; Astleford, Bret A.; Brennan, John; Stout, James R.; Tharp-Taylor, Roger W. Organic Process Research and Development, 2009 , vol. 13, # 2 p. 280 - 284

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被引用次数: 44

摘要

Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of sulfonate esters as potential genotoxic impurities (PGIs). Whilst sulfonate esters could theoretically result from interaction between sulfonic acids and alcohols, literature on their formation is sparse. GC− MS analysis of reactions of ...