Mechanism and processing parameters affecting the formation of methyl methanesulfonate from methanol and methanesulfonic acid: an illustrative example for …

…, S Golec, R Schulte Oestrich, P Sandra…

Index: Magnus, Nicholas A.; Astleford, Bret A.; Brennan, John; Stout, James R.; Tharp-Taylor, Roger W. Organic Process Research and Development, 2009 , vol. 13, # 2 p. 280 - 284

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Citation Number: 44

Abstract

Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of sulfonate esters as potential genotoxic impurities (PGIs). Whilst sulfonate esters could theoretically result from interaction between sulfonic acids and alcohols, literature on their formation is sparse. GC− MS analysis of reactions of ...