Organic letters

O-Nucleophilic amino alcohol acyl-transfer catalysts: the effect of acidity of the hydroxyl group on the activity of the catalyst

KA Wayman, T Sammakia

文献索引：Wayman, Kjirsten A.; Sammakia, Tarek Organic Letters, 2003 , vol. 5, # 22 p. 4105 - 4108

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被引用次数: 22

摘要

Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.