Identification and optimisation of 5-amino-7-aryldihydro-1, 4-diazepines as 5-HT 2A ligands

CJ Swain, A Teran, M Maroto, A Cabello

文献索引：Swain, Christopher J.; Teran, Ana; Maroto, Marta; Cabello, Angeles Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6058 - 6062

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被引用次数: 8

摘要

A several series of low molecular weight 5-HT 2A leads were identified from an analysis of HTS data, the exploration of SAR and optimization of one series using parallel synthesis are described, affording compound 22 (5-HT 2A IC 50 1.1 nM). ... A several series of low molecular weight 5-HT 2A leads were identified from an analysis of HTS data, the exploration of SAR and optimisation one series using parallel synthesis is described affording compound 22 ...