Helvetica Chimica Acta

A New Route to the Synthesis of 2??Amino??6??(methoxycarbonyl) amino??4??(tetrahydropyridyl) pyrimidine 1??Oxide

JC Muller, H Ramuz, HP Wagner

文献索引：Muller, Jean-Claude; Ramuz, Henri; Wagner, Hans-Peter Helvetica Chimica Acta, 1983 , vol. 66, # 3 p. 809 - 813

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被引用次数: 6

摘要

Abstract A new approach to 2-amino-6-(methoxycarbonyl) amino-4-(1, 2, 3, 6-tetrahydro-1- pyridyl) pyrimidine 1-oxide (3) is described. Methyl [1-ethoxy-2-(ethoxycarbonyl)-ethylidene] carbamate (5) reacted with guanidine to the pyrimidinecarbamate 6, which was successively transformed into methyl 2-amino-6-(p-tolyslulfonyl) oxy-4-pyrimidinecarbamate (8). Oxidation of 8 led to the corresponding pyrimidine N-oxide 9, a useful starting material to 3.