Abstract A new approach to 2-amino-6-(methoxycarbonyl) amino-4-(1, 2, 3, 6-tetrahydro-1- pyridyl) pyrimidine 1-oxide (3) is described. Methyl [1-ethoxy-2-(ethoxycarbonyl)-ethylidene] carbamate (5) reacted with guanidine to the pyrimidinecarbamate 6, which was successively transformed into methyl 2-amino-6-(p-tolyslulfonyl) oxy-4-pyrimidinecarbamate (8). Oxidation of 8 led to the corresponding pyrimidine N-oxide 9, a useful starting material to 3.
![methyl (NZ)-N-[2-amino-6-(3,6-dihydro-2H-pyridin-1-yl)-3-hydroxy-pyrimidin-4-ylidene]carbamate Structure](https://image.chemsrc.com/caspic/113/74025-90-4.png)
