Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli

Y Han, S Hou, KA Simon, D Ren, YY Luk

文献索引：Han, Yongbin; Hou, Shuyu; Simon, Karen A.; Ren, Dacheng; Luk, Yan-Yeung Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1006 - 1010

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被引用次数: 55

摘要

A collection of structurally closely related furanones was synthesized to identify the most important structural elements in brominated furanones for inhibiting the formation of bacterial biofilms. The results suggest that a conjugated exocyclic vinyl bromide on the furanone ring is the most important structural element for the non-toxic but inhibition activity for Escherichia coli biofilm formation. Furanones bearing monosubstituted bromide groups on saturated ...