" Safety-Catch" Protecting Groups in Peptide Synthesis

M Pátek, M Lebl

文献索引：Patek, Marcel; Lebl, Michal Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 3 p. 508 - 524

全文：HTML全文

被引用次数: 6

摘要

Abstract A new benzhydryl-type protective groups for amides based on the concept of converting a stable protecting group into a labile one (safety-catch principle) are described. The p-substituted benzhydrylamine derivatives III (a, b), IV (a, b) are shown to be labile toward various acids but in their oxidized state-V (a, b), VI (a, b) exhibit the resistance to conditions commonly used for removal the Boc group. Independent removal of Boc or ...