Abstract A new benzhydryl-type protective groups for amides based on the concept of converting a stable protecting group into a labile one (safety-catch principle) are described. The p-substituted benzhydrylamine derivatives III (a, b), IV (a, b) are shown to be labile toward various acids but in their oxidized state-V (a, b), VI (a, b) exhibit the resistance to conditions commonly used for removal the Boc group. Independent removal of Boc or ...
[Gabbutt, Christopher D.; Heron, B. Mark; Kolla, Suresh B.; Kilner, Colin; Coles, Simon J.; Horton, Peter N.; Hursthouse, Michael B. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 17 p. 3096 - 3104]
