Synthesis of sanguinarine, chelerythrine, and oxysanguinarine

J Šmidrkal

文献索引：Smidrkal, Jan Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1412 - 1420

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被引用次数: 16

摘要

A series of benzo[ c ]phenanthridine alkaloids have already been prepared by total syntheses 1 - 9. The methods described in the present communication are simple and suitable for synthesis of larger amounts of these alkaloids. The key point of this synthesis consisted in solution of preparation of 6-bromo- -2,3-methylenedioxybenzaldehyde10 (I a). From aldehyde I a and naphthylamine6 II the Schiff's base IlIa was prepared which was reduced with NaBH4 to amine IVa. ...