Synthesis of sanguinarine, chelerythrine, and oxysanguinarine

J Šmidrkal

Index: Smidrkal, Jan Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1412 - 1420

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Citation Number: 16

Abstract

A series of benzo[ c ]phenanthridine alkaloids have already been prepared by total syntheses 1 - 9. The methods described in the present communication are simple and suitable for synthesis of larger amounts of these alkaloids. The key point of this synthesis consisted in solution of preparation of 6-bromo- -2,3-methylenedioxybenzaldehyde10 (I a). From aldehyde I a and naphthylamine6 II the Schiff's base IlIa was prepared which was reduced with NaBH4 to amine IVa. ...