Sulfonamides as selective oestrogen receptor β agonists

…, M MacKenny, C Phillips, N Pullen, A Stennett…

文献索引：Roberts, Lee R.; Armor, Duncan; Barker, Carolyn; Bent, Andrew; Bess, Kirstin; Brown, Alan; Favor, David A.; Ellis, David; Irving, Stephen L.; MacKenny, Malcolm; Phillips, Chris; Pullen, Nick; Stennett, Adam; Strand, Linda; Styles, Michelle Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5680 - 5683

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被引用次数: 8

摘要

A series of p-hydroxybenzenesulphonamides ERβ receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERα receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERβ agonists.