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. alpha.-Substitution of amines via dipole stabilized carbanions from formamidines

AI Meyers, W Ten Hoeve

文献索引:Meyers, A. I.; Hoeve, Wolter Ten Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7125 - 7126

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被引用次数: 54

摘要

Deprotonation and alkylation of the a carbon of amines has been effected in various ways which involve the use of a masked amino Prominent among these methods is the use of N- nitroso amines4 and NJV-dimethylamide~.~ However, the potential carcinogenicity of the former and the steric bulk required in the latter render these approaches to alkylated amines less than desirable.