Synthesis of a new insoluble polymer-supported chiral alcohol auxiliary and its first application to nucleophilic addition to ketenes

R Akkari, M Calmes, N Mai, M Rolland…

文献索引：Akkari; Calmes; Mai; Rolland; Martinez Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5859 - 5865

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被引用次数: 33

摘要

The preparation of a new optically active alcohol with a carboxylic function that allowed its attachment to an amine-functionalized insoluble polymer is described. Its first use as a polymer supported chiral auxiliary is demonstrated by asymmetric transformation of two racemic aryl propionic acids via ketene formation (95-96% ee).