Tetrahedron Letters

An effective kinetic resolution of racemic α-arylpropanoic acids, α-arylbutanoic acids, and β-substituted-α-arylpropanoic acids with bis (9-phenanthryl) methanol as a …

K Nakata, Y Onda, K Ono, I Shiina

文献索引：Nakata, Kenya; Onda, Yu-Suke; Ono, Keisuke; Shiina, Isamu Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5666 - 5669

全文：HTML全文

被引用次数: 11

摘要

A general method for the kinetic resolution of racemic α-arylalkanoic acids with achiral alcohols is described. It was determined that bis (9-phenanthryl) methanol is a suitable nucleophile which reacts with the intermediary mixed anhydrides generated from aromatic anhydrides with α-arylpropanoic acids or β-substituted-α-arylpropanoic acids in the presence of (+)-benzotetramisole to produce the corresponding optically active esters with ...