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The Synthesis and Immunotropic Activity of a New Azathioprine Analog–2-Amino-6-(1-ethyl-2-methyl-4-nitroimidazolyl-5-mercapto) purine

…, LS Tolvinskaya, IB Zhukova, VG Pukhal'skaya…

文献索引:Kochergin; Aleksandrova; Tolvinskaya; Zhukova; Pukhal'skaya; Telegin; Pevnitskii; Korsunskii Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 11 p. 579 - 581

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摘要

Azathioprine (Az) is among the currently available effective immunodepressants which is widely used in the treatment of autoimmune and rheumatic diseases [1, 2], idiopathic pulmonary fibrosis [3], clinical transplantation [4–6], etc. However, this agent has a narrow therapeutic ratio [7] and produces serious side effects [8, 9]. Thus, the search for new immunodepressants remains important in contemporary theoretical and practical ...