Azathioprine (Az) is among the currently available effective immunodepressants which is widely used in the treatment of autoimmune and rheumatic diseases [1, 2], idiopathic pulmonary fibrosis [3], clinical transplantation [4–6], etc. However, this agent has a narrow therapeutic ratio [7] and produces serious side effects [8, 9]. Thus, the search for new immunodepressants remains important in contemporary theoretical and practical ...