Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1, 3, 4-thiadiazole-2-yl] piperazinyl quinolones

A Foroumadi, S Mansouri, Z Kiani…

文献索引：Foroumadi, Alireza; Mansouri, Shahla; Kiani, Zahra; Rahmani, Afsaneh European Journal of Medicinal Chemistry, 2003 , vol. 38, # 9 p. 851 - 854

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被引用次数: 171

摘要

A series of N-[5-(5-nitro-2-thienyl)-1, 3, 4-thiadiazole-2-yl] piperazinyl quinolones (7a–c) were synthesized and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that compounds 7a–c had strong and better activity against tested Gram-positive organisms than the reference quinolones such as ciprofloxacin, norfloxacin and enoxacin. However, all three ...