A series of N-[5-(5-nitro-2-thienyl)-1, 3, 4-thiadiazole-2-yl] piperazinyl quinolones (7a–c) were synthesized and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that compounds 7a–c had strong and better activity against tested Gram-positive organisms than the reference quinolones such as ciprofloxacin, norfloxacin and enoxacin. However, all three ...
![[(5-nitrothiophen-2-yl)methylideneamino]thiourea Structure](https://image.chemsrc.com/caspic/280/5351-83-7.png)
