Synthesis and antifungal activities of R-102557 and related dioxane-triazole derivatives.

S Oida, Y Tajima, T Konosu, Y NAKAMURA…

文献索引：Oida, Sadao; Tajima, Yawara; Konosu, Toshiyuki; Nakamura, Yoshie; Somada, Atsushi; Tanaka, Teruo; Habuki, Shinobu; Harasaki, Tamako; Kamai, Yasuki; Fukuoka, Takashi; Ohya, Satoshi; Yasuda, Hiroshi Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 694 - 707

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被引用次数: 23

摘要

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11-13 under acidic conditions afforded a series of dioxane-triazole compounds 14-16. The antifungal activities of the compounds 14- 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond (s) and ...