Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation
Binding of the multimeric adhesive protein fibrinogen (Fg) to activated GPIIb/IIIa platelet plasma membrane receptors is believed to be an important step for platelet aggregation, l4 Platelet activation (stimulated by a variety of agents such as ADP, thrombin, and epinephrine) and aggregation are involved in thrombus formation and other pathophysiological processes in atherosclerosis and related vasoocclusive disorders. 6f6 ...
