Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation

…, SM Hwang, TW Ku, MA Lago, AJ Nichols…

Index: Ali; Bennett; Calvo; Elliott; Hwang; Ku; Lago; Nichols; Romoff; Shah; Vasko; Wong; Yellin; Yuan; Samanen Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 769 - 780

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Citation Number: 85

Abstract

Binding of the multimeric adhesive protein fibrinogen (Fg) to activated GPIIb/IIIa platelet plasma membrane receptors is believed to be an important step for platelet aggregation, l4 Platelet activation (stimulated by a variety of agents such as ADP, thrombin, and epinephrine) and aggregation are involved in thrombus formation and other pathophysiological processes in atherosclerosis and related vasoocclusive disorders. 6f6 ...