Antimalarial potency of 2-benzoyl-4-quinolinemethanols

…, S Kano, T Kikuchi, K Okubo, M Shinbo

文献索引：Saggiomo; Kano; Kikuchi; Okubo; Shinbo Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 989 - 994

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被引用次数: 8

摘要

A major effort in the potent antimalarial series of 2-phenyl-4q~ inolinemethanols'~~ has been the design of effective members without phototoxicity." Since the majority of agents causing phototoxic reactions are conjugated aromatic structures>-'it seemed desirable in the above series to insulate the 2-phenyl substituent from the quinoline nucleus by a C atom. For this purpose we investigated, initially, the 4quinolinemethanol derivatives (Ia, b, and j ...