A major effort in the potent antimalarial series of 2-phenyl-4q~ inolinemethanols'~~ has been the design of effective members without phototoxicity." Since the majority of agents causing phototoxic reactions are conjugated aromatic structures>-'it seemed desirable in the above series to insulate the 2-phenyl substituent from the quinoline nucleus by a C atom. For this purpose we investigated, initially, the 4quinolinemethanol derivatives (Ia, b, and j ...
