Helvetica chimica acta

Asymmetric catalysis by Vitamin B12: The isomerization of achiral aziridines to optically active allylic amines

ZD Zhang, R Scheffold

文献索引：Zhang, Zhong da; Scheffold, Rolf Helvetica Chimica Acta, 1993 , vol. 76, p. 2602 - 2615

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被引用次数: 71

摘要

Achiral N-acylaziridines are isomerized to optically active N-acyl-allylamines in eels of up to 95 % by catalytic amounts of cob(1)alamin in MeOH. ... Introduction. - Allylamines and their derivatives are important intermediates in organic synthesis, and many of them show biological activity as antimycotics like naftifine [ 11, SF 86-327 [2], and 1-aminocycloalk-2-enes [3], as neurotoxins like gabaculine [4], as antibiotics like oryzoxymycin [5], and as compounds with potential ...