Synthesis of (1, 4)-naphthoquinono-[3, 2-c]-1H-pyrazoles and their (1, 4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents

VK Tandon, DB Yadav, AK Chaturvedi…

文献索引：Tandon, Vishnu K.; Yadav, Dharmendra B.; Chaturvedi, Ashok K.; Shukla, Praveen K. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 13 p. 3288 - 3291

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被引用次数: 63

摘要

A series of (1, 4)-naphthoquinono [3, 2-c]-1H-pyrazoles and their (1, 4)- naphthohydroquinone derivatives 2–7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure–activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also ...